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Whole-body imaging was performed for six subjects, skin type 1-VI, with generalized vitiligo diagnosed by a dermatologist. Subjects were positioned at the centre of the imaging system. 1a), comprised of 46 cameras, are 2.8 m 9 2.4 m 9 2.4 m, for the x, y and z dimension, respectively. The physical dimensions of the Canfield Vectra WB 360 system (Fig. The use of high-resolution Canfield Vectra Whole Body 360 (WB360) allowed for taking of 3D images of the entire body of the vitiligo subject at once. Published by John Wiley & Sons Ltd Experimental Dermatology, 2015, 24, 879–880 Further comparisons were made to compare lesion area calculated by 2D and 3D image analyses. Questions addressed The objective of this work was to accurately quantify the vitiligoaffected BSA by analysing 3D images of vitiligo subjects and evaluating data for reliability measures, where reliability refers to consistent repeated measurements. Other research groups (8,9) (S9–S11) have validated the accuracy and utility of 3D imaging and analysis for a range of clinical applications, and we have extended this utility to evaluate vitiligo. In this letter, we describe this emerging technique of taking whole-body 3D images followed by 3D image analysis to quantify the vitiligo-affected body surface area (BSA) of the subjects. Unfortunately, although there have been many qualitative and semiquantitative outcome measures (2–7) (brief discussion in e-supplement), there is no standardized outcome method to determine the treatment efficacy for vitiligo. It can be a very psychologically distressing disease that can negatively affect the subject’s quality of life (2). It affects 1–2% of the world population and affects all skin types (1). Vitiligo is a skin disorder that results from the loss of pigmentation (S8) due to the destruction of melanocytes. Time required for 3D image acquisition and for analysing total vitiligo-affected BSA was evaluated for each subject. Key words: body Surface Area (BSA) – imaging – Measurement error – three dimensional – vitiligoĪffected by vitiligo was thus calculated. Hamzavi, MD, Department of Dermatology, Henry Ford Medical Center – New Center One, 3031 West Grand Blvd, Suite 800, Detroit, MI 48202, USA, Tel.: +31, Fax: +31, e-mail: Lim1 and Iltefat Hamzavi1 1 Department of Dermatology, Multicultural Dermatology Center, Henry Ford Hospital, Detroit, MI, USA 2Canfield Scientific, Inc., Fairfield, NJ, USA 3Independent, Boston, MA, USA Correspondence: Iltefat H.
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